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Excessive or deficient copper levels can, however, lead to cytotoxicity and pathological alterations [7]

A significant percentage of corticotroph adenomas harbor somatic mutations in USP8, and a germline mutation case have also been described and can develop Cushings disease (147,150,151)

This indicated enhanced ferroptosis in fibroblast-like synoviocytes (FLSs) by downregulating PI3K-AKT-ERK1/2 signaling pathway and the activation of the P53 pathway which collectively contributed to reduced cell proliferation, migration, and invasion of FLSs

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