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This chapter seeks to address these issues and give pathologists a framework with which to handle these challenging specimens

It is orally dissolved and fast-acting

Although the term PEM allows one to deal with diagnostically challenging pigmented melanocytic tumors, for which a reliable distinction between melanoma and an unusual pigmented nevus is difficult or impossible by light microscopic examination alone, we caution against labeling lesions as PEM, which previously would have been diagnosed as benign EBN or pigmented dermal spindle and epithelioid cell nevus

The Molecular Pathology of Melanoma: An Integrated Taxonomy of Melanocytic Neoplasia