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To carry out this reductive reaction, Complex I binds flavin and, depending on the organism, up to ten Fe-S clusters 47

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Under normal conditions, microglia maintain neuronal function through synaptic pruning, but in early AD, hyperactive neurons trigger aberrant microglial phagocytosis, causing synaptic loss and disrupted neural signaling (Zhong L

Unlike GPx1GPx4, GPx5 does not contain selenocysteine but contains cysteine residues in the active site, and GPx5 does not exhibit typical dismutation activity toward substrates such as H 2 O 2 (Taylor et al