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Neuron 12 : 10311040

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After the HO-1-catalysed reaction, the iron is released from the haem group and is stored inside the ferritin.101 The expression of ferritin is regulated by the concentration of iron and the HO-1 activity.102 This protein plays a crucial role in diseases related to haemoproteins, as ferritin-deficient rats show notable renal damage,103 and it is a good serum marker for SCA.104 Plasma levels of Tf are also higher in ferritin-deficient rats that are subjected to rhabdomyolysis.103 Nrf2 Nrf2 is a transcription factor that controls the expression of several antioxidant genes such as HO-1 and ferritin.105,106 Under normal conditions, Nrf2 is found in the cytoplasm bound to its repressor Keap1, which is susceptible to changes in the redox state and is subjected to proteolytic degradation through the proteasome

While Henry Meds offers slightly lower total costs if you include lab work, you must prepay before consultations and you dont get unlimited doctor access