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Recent studies have shown that any adverse change in the functional or structural nature of the astrocytes directly influences the activity of neurons, consequently leading to neurodevelopmental and neurological disorders (Liu et al., 2021

However, glutathiones relative distribution within cells is difficult to determine because oxidized glutathione (GSSH) rapidly recycles back to reduced glutathione (GSH)

88,89,90 Oxidative stress can modify ATM through cysteine oxidation, phosphorylation, and acetylation, 91 which leads to ATM activation and subsequent phosphorylation of downstream proteins independent of MRN

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