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270 The proinflammatory and profibrotic effect of NLRP3 inflammasome has been confirmed in multiple animal models of kidney diseases such as UUO, angiotensin II-induced hypertensive kidney injury, DN, glomerulonephritis, and 5/6 nephrectomy

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[00020] In another embodiment, the invention provides a formulation (e.g., a solid unit dosage such as a tablet) comprising 1800-2200 IU vitamin D (cholecalciferol), 34-39 mg vitamin C, 1.4-1.8 mg vitamin B 6 (pyridoxine HC1), 8-12 meg vitamin B 12 (cyanocobalamin), 14-18 mg magnesium, 82-86 meg of selenium (selenium yeast), 135-139 mg ginko biloba extract powder, and 30-40 mg EHT extract