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The evaluation of RPM supplementation over a 3-month period in rams showed positive effects in increasing serum testosterone and scrotal circumference ( Considering the importance of methionine (MET) as a methyl donor in DNA methylation processes, studies have investigated the effects of RPM supplementation in males on epigenetic regulation, as well as on gene and protein expression profiles related to sperm quality and seminal plasma composition

Zhang Z, Wang S, Diao Y, Zhang J, Lv D

Mechanistically, we reveal that VRK2 inhibition disrupts endoplasmic reticulum (ER)-to-Golgi trafficking of SLC7A11, consequently diminishing GSH biosynthesis and predisposing PC cells to ferroptosis

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