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As CoPP structurally mimics heme but cannot be efficiently degraded by HO-1, CoPP treatment has been proposed as a potential therapeutic strategy for oxidative stress-related diseases, including cardiovascular disease 65,66 , diabetes 67 , obesity 68 , septic insults 65 , and metabolic syndrome 69

Ruscito A

For this analysis, the datasets for the three timepoints (1, 6, and 20 months) were processed independently and were not integrated prior to UMAP visualization