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Indeed, a cellular dependence on PPP was described in cancer cells that are heavy cystine importers, requiring NADPH for cystine to cysteine intracellular conversion (76)

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J Biol Chem 273:3273932745 Noji M, Saito K (2002) Molecular and biochemical analysis of serine acetyltransferase and cysteine synthase towards sulfur metabolic engineering in plants