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6 Phase I reactions are frequently mediated by cytochrome P450 enzymes, such as CYP2E1 in the case of acetaminophen

In a neonatal piglet-based ARDS model, it was found that experimental supplementation with phosphatidylglycerol reduced interleukin-6 (IL-6) and alveolar apoptosis while preserving the alveolar-capillary barrier, thereby reducing pulmonary edema

Interestingly, the categories enriched in the upregulated clusters are related to phagosome maturation, RNA and translation, but importantly multiple metabolism pathways including citric acid cycle, cholesterol metabolism, pentose phosphate pathway, electron transport chain, and glutathione metabolism

Importantly, PAD4-mediated citrullination significantly inhibits the aggregation of FET proteins 113