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As for orally administered drugs, their bioavailabilities are often below 100 % (F 1 nm diameter) to pass through

Nature 454 , 345349 (2008)

ROC analysis of adduct levels in serum from patients known to have APAP hepatotoxicity showed that an APAP protein adduct level 1.1 nmol/mL had a high sensitivity and specificity (96.8 and 95.0 %, respectively) for patients with APAP overdose and ALT levels above 1000 IU/L