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Preclinical Obesity (PCO), considering BMI 25 kg/m 2 with increased abdominal adiposity or BMI 40 kg/m 2 alone, without clinical signs or symptoms of organ dysfunction

LOX-1 is responsible for binding, being internalized, and proteolytically degrading oxLDL but not acetylated LDL, and thus mediates foam cell formation in atherosclerotic plaques (35)