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RhoA/ROCK Pathway: [141,142,143,144,145,146] PI3K/AKT Pathway: [70,147,148,149] WNT/-catenin Pathway: [124,150,151,152,153,154,155,157,158,159,160] SHH Pathway: [161,162,163]

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Whereas this represents a significant improvement in speed due to recent computational advancements, the authors of the latest pKa predictor model QupKake, emphasize the need for a faster replacement for these semiempirical calculations 28