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Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux

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Diacetyl and 2,3-pentanedione exposures associated with cigarette smoking: Implications for risk assessment of food and flavoring workers Crit Rev Toxicol, 2014

Although the increased generation of NADPH oxidase-derived oxidants by neutrophils mediated by HOCl-modified plasma proteins can accelerate pathogen clearance at the site of an acute infection, prolonged lifespan of neutrophils due to inhibited apoptosis can also delay the resolution of inflammation, thus providing a positive feedback loop that may ultimately lead to chronic inflammation