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Over weeks and months of therapy, this reduced intake can lead to declining B12 levels

Early symptoms typically include ongoing fatigue, low energy, brain fog, difficulty concentrating, weakness, and mood changes such as irritability or low motivation

doi: 10.3389/fimmu.2026.1730351 Received 22 October 2025 Revised 28 January 2026 Accepted 24 February 2026 Published 25 March 2026 Volume 17 - 2026 Edited by Chafia Touil-Boukoffa, University of Science and Technology Houari Boumediene, Algeria Reviewed by Nar Singh Chauhan, Maharshi Dayanand University, India Fatma Naz Cemre Kalayci, DanaFarber Cancer Institute, United States Updates Copyright 2026 Zhan, Wang, Zhan, Yang, Liang, Yu and Wang

In clinical nutrition practice, Vitamin D and B12 deficiency is frequently identified in working professionals, women with hormonal imbalance, vegetarians, elderly individuals, and even young adults who appear otherwise healthy