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Combination with finerenone for cardiorenal protection Recently, in FIDELIO-DKD [52], FIGARO-DKD [53] and their pooled meta-analysis FIDELITY [11], finerenone has also been shown to reduce cardiovascular and renal events in CKD patients with diabetes

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Park J.M., Lee H.J., Sikiric P., Hahm K.B

thereby, p53 may target pro-apoptotic genes and promote their expression