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It continues to be included into multidisciplinary cancer care because, in certain cases, it can provide more patients long-lasting disease management ( Additionally, the physical makeup of the tumor environment, including increased stiffness, high interstitial fluid pressure (IFP), and solid stress, poses significant challenges to delivering cancer drugs effectivelyespecially in dense tumors ( Aptamer technology was developed in the 1990s, simultaneously, by two independent groups, Tuerk and Gold ( This article examines the innovative application of aptamers in cancer immunotherapy, with a focus on solid tumors