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In therapeutic and commercial applications of exogenous mRNA these modifications (Figure 3) are made in order to increase translation initiation, improve expression and reduce immunogenicity [ FIGURE 3 It is recorded that innate immune system differentiates self-originating mRNA from IVT mRNA triggering immune responses via pattern recognition receptors (PRRs)

The dementia that is treated according to methods of the present invention may also be the result of other conditions or illnesses

[DOI] [PubMed] [Google Scholar] 76.Christen W.G., Cook N.R., Van Denburgh M., Zaharris E., Albert C.M., Manson J.E

Pro-angiogenic BPC157 associated with VEGFR2 activation and up-regulation