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While most clinical evidence supports a favorable safety profile at typical therapeutic doses, caution is warranted as higher doses may cause sedation, cardiovascular effects such as hypotension and arrhythmias, and, in rare cases, respiratory depression

Their findings imply a potential role of melatonin deficiency in COVID-19-associated depression, anxiety, and insomnia, which encourages further research to deploy melatonin in COVID-19 patients with such complications

This biochemical synergy is one reason why Pinealon effects on mood tend to become more pronounced over the four-to-six-week timeline, as the circadian system progressively normalizes

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