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171 Microglia, the CNS foremost innate immune cells, acts as an initial defense against danger-associated molecular patterns and pathogen-associated molecular pattern receptors

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Limitations include limited large-scale human clinical evidence, challenges in extrapolating in-vitro concentrations to in-vivo contexts, stability sensitivities (light, heat, alkaline pH), and variability in supplier purity

BAT, distinguished by its high mitochondrial density and extensive vascularization, dissipates energy by nonshivering thermogenesis, whereas WAT primarily serves as an energy storage depot and secretes a variety of metabolic hormones and cytokines [210]