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Short-chain fatty acids are substances produced primarily by anaerobic bacteria in the intestinal tract through the fermentation of undigested carbohydrates, and usually have significant physiological regulatory functions, such as protecting the intestinal mucosal barrier and inhibiting intestinal inflammation ( Accumulating evidence establishes the gut microbiota as a critical regulator in functional constipation pathogenesis ( Artemisia argyi polysaccharide (AAP) has been demonstrated to alleviate intestinal inflammation and gut microbiota dysbiosis in mice, playing a crucial role in maintaining intestinal barrier integrity (Figures 6B, C)

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428,429 However, the reported findings are inconsistent, possibly due to selection bias and small study sizes

Identifying the structural determinants of the ligand-stimulated transport of GSH by MRP1 is critical to understand the mechanism by which MRP1 regulates the GSH homeostasis and to allow the design of future CS agents that can selectively kill MRP1-overexpressing chemoresistant cancer cells