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*Based on clinical testing conducted by HLK Clinical Center Ltd

Interestingly, this effect was prevented by the administration of gadolinium chloride, which is an inhibitor of liver-residing macrophages known as Kupffer cells (68)

We previously identified F--DDB-derivative, a novel synthetic of bifendate, as a potential agent to improve the therapeutic efficacy of TNBC in combination with EPI since F--DDB-derivative inhibited MDA-MB-468, but not as much as EPI

In old rats and mice compared to young, arginase activity was significantly increased and accompanied by decreased NO production and increased O 2 generation indicating eNOS uncoupling [129, 130]