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A newborn with male phallus or hypospadias, atypical external genitalia and bilateral non-palpable gonads is potentially a genetic female (46,XX) with congenital adrenal hyperplasia due to 21-hydroxylase deficiency or another rare defect of adrenal and gonadal steroidogenesis (11 beta-hydroxylase deficiency, steroidogenic acute regulatory protein (StAR) or cholesterol side-chain cleavage enzyme defect)

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GHK-Cu upregulated the Nrf2/Keap1 pathway Nrf2 is attached to Keap1 in the cytoplasm under normal circumstances, while in the condition of stress, the stimuli of oxidative stress activate the separation of Nrf2 and Keap1 and translocate Nrf2 to the nucleus and switch on transcriptional activities (Itoh et al., 1997)