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C (101 MHz, MeOD): 174.48 (C), 172.98 (C), 172.59 (C), 172.27 (C), 171.52 (C), 162.11 (q, J = 35.7 Hz, (C)), 136.28 (d, J = 3.0 Hz, CH), 134.81 (d, J = 10.0 Hz, CH), 131.54 (d, J = 12.6 Hz, CH), 119.94 (d, J = 86.3 Hz, C), 54.01 (CH), 53.51(CH), 41.80 (CH 2 ), 40.09 (CH 2 ), 36.19 (CH 2 ), 35.25 (CH 2 ), 32.36 (CH 2 ), 29.46 (CH 2 ), 28.71 (d, J = 16.8 Hz, CH 2 ), 27.06 (CH 2 ), 23.16 (d, J = 4.3 Hz, CH 2 ), 22.66 (d, J = 51.3 Hz, CH 2 )

Agents already in routine practicebevacizumab, trastuzumab and mirvetuximab soravtansineprovide compelling clinical precedents, while pipeline ADCs and recombinant modulators promise an expanding repertoire of ovary-sparing therapeutics

Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of Schizophrenia

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