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Fourth, DN involves multiple regulated cell-death pathways with potential crosstalk, and since apoptosis-related proteins (such as the caspase family) and autophagy markers (such as LC3 and p62) were not assessed, it cannot be excluded that DAPA also modulates these pathways and contributes to the observed protective effects

Although the body produces some of its own glutathione, poor diet, smoking, air pollution, stress, infections and radiation reduce the proportion of glutathione in the body

Activation of c-Jun-N-terminal kinase is required for apoptosis triggered by glutathione disulfide in neuroblastoma cells