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The mechanistic literature leans against a classic tolerance effect, not toward it

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Three authors (MM, AN, and JV) independently screened titles and abstracts following de-duplication

Basically, cyanocobalamin needs to be broken down to cobalamin and cyanide in order to convert to the active form of B12, and some researchers have concerns about the effects of cyanide accumulation in the body with long-term use of cyanocobalamin but the jurys still out on whether thats a cause for concern

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