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In urinary and male reproductive tract infections caused by uropathogenic Escherichia coli (UPEC), UPEC suppresses the host cell AKT signaling pathway via its virulence factor -hemolysin, resulting in a marked reduction in histone H4 acetylation levels (ChIP-qPCR shows P 60% to ~20%thereby inhibiting ASC-mediated assembly and activation of the NLRP3 inflammasome [282]