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that identified CJC-1295 as a long-lasting GRF analogue via albumin bioconjugation simultaneously confirmed the pharmacological profile of the tetrasubstituted GRF backbone showing a 4-fold increase in GH area under the curve over a 2-hour period compared to native hGRF(1-29) in rats, with all three maleimido derivatives of the same tetrasubstituted scaffold demonstrating enhanced DPP-4 stability and full GHRH receptor bioactivity in anterior pituitary cell assays

Proprits antioxydante et anti-inflammatoire Rle dtoxifiant: limination des toxines Hong SY, Gil HW, Yang JO, Lee EY, Kim HK, Kim SH, Chung YH, Hwang SK, Lee ZW (2005)

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This is an interesting point when you consider that in prostate cancer it has been shown that estrogen can substitute to upregulate IGF-1R when androgen levels are low (Turcu et al., 2017)