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This results in marked reduction in the number of capillaries per muscle fiber and dilatation of the remaining capillaries in an effort to compensate for impaired perfusion

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In parallel, butyrate also functions as a histone deacetylase (HDAC) inhibitor, influencing epigenetic gene expression ( reg ) differentiation, induce antimicrobial peptide expression (e.g., -defensins, RegIII), and maintain epithelial barrier integrity (Isobe et al., 2020