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Kibugu J, Munga L, Mburu D, Maloba F, Auma JE, Grace D, et al

After initiation and dose increases, patients should be observed carefully for signs and symptoms of pancreatitis (including persistent severe abdominal pain, sometimes radiating to the back and which may or may not be accompanied by vomiting)

In PTC and ATC cell lines, aurora-A, a member of the aurora serine/threonine kinase family, induces glycolysis by activating 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), and the inhibition of aurora-A with its selective inhibitor, alisertib, has been shown to improve the efficacy of sorafenib in both PTC and ATC cells [77]