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Description

Tirzepatide once weekly for the treatment of obesity (SURMOUNT-1)

Key Research Properties: Small molecule NNMT (nicotinamide N-methyltransferase) inhibitor Modulates NAD+ metabolism and methylation capacity Studied in context of energy expenditure and metabolic regulation NNMT is upregulated in obesity

The therapy applies these to mimic the system where these stimulate certain hormones and processes inside the body to aid in weight management

It is important to note that all current evidence derives from in vitro cellular models and in vivo animal studies, and no human clinical trials have been conducted as of February 2026