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However, this depends on the cause

Within the realm of bone tissue engineering, this microenvironment comprises both osteogenic and immune cell lineages, including mesenchymal stem cells (MSCs) and pre-osteoblasts as the principal osteogenic cells, and macrophages as the dominant immune cells ( The complexity of the bone defect microenvironment makes cells vulnerable to various factors during regeneration and repair, creating substantial challenges for bone healing and clinical implementation of bone tissue engineering

In particular, the authors reported that increased methylation levels of APC not only differentiated HCC patients from healthy individuals but also predicted clinical outcomes, since higher methylation levels were detected in stage III/IV compared to stage I/II HCC patients [201]

they can bind miRNAs competitively and act as a miRNA sponge to play a role 59