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Molecular analysis of three gain-of-function CHO mutants that add the bisecting GlcNAc to N-glycans

To validate extraction protocol of all six metabolites from whole blood we used spiking approach

found that overexpression of an alternative translation product of ARF (p19), namely, short mitochondrial ARF (smARF), led to an abnormal mitochondrial membrane potential and promoted mitophagy-mediated ADCD [58]

During mastication they are enzimatically converted into thiocyanates, goitrin metabolites, that cause a competitive inhibition of the sodium/iodide symporter, thus inhibiting the thyroid hormones synthesis and possibly causing hypothyroidism [156]