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Pharmacokinetic analysis in this trial revealed a critical association between drug exposure and toxicityhigher drug exposure was associated with a higher incidence of oral ulcers ( P = 0.047), and this was more pronounced in patients requiring dose reduction [117]highlighting the importance of balancing efficacy and safety through therapeutic drug monitoring

All three dogs' CHF were resolved following treatment, although the success cannot be attributed to the IV-NTG because of the small number of cases and the other medications used to treat the dogs' conditions

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Apoptotic cell death consequent to the ocular hypertone is controlled in the presence of carnitine To assess weather carnitine can actually reduce the execution of apoptosis after induction of the hypertone, we evaluated the extent of cell death by TUNEL staining and detection of a commonly accepted marker of apoptosis: caspase 3