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Among the SHANK isoforms, the SHANK3 gene is most closely associated with ASD and related neurodevelopmental conditions such as Phelan-McDermid syndrome

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To examine whether the administration of the Si-based agent alleviates the visceral pain and discomfort associated with UC, we investigated the neuronal activities in the nuclei of the dorsal medulla oblongata [the nuclei of the solitary tract (NST) and the dorsal vagal nuclei (DVN)], and the central amygdala (CeA) using immunostaining for c-Fos, a neuronal active marker

Moreover, evidence from clinically relevant studies also showed the elevated levels of proinflammatory cytokines in postmenopausal populace [24,25]