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Isochoric approaches could either boost one of these or be completely enabling by, for instance, allowing a specific approach to be practical without the need for using toxic levels of CPA

The authors concluded that the senescent microenvironment maintained by SASP and p53-pS15 signalling promotes keloid aggressiveness and relapse, and that FOXO4-DRI targets this mechanism selectively

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To trigger necrotic cell death, Mtb used focal adhesion kinase (FAK) in a time-dependent manner, first by exploiting RIPK1 and then, to a lesser extent, by using RIPK3-MLKL, to produce ROS ( 5.1.5 Pyroptosis Additionally, Mtb escape host clearance involves pyroptosis control