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Their relatively simple architectures, combined with the accuracy with which they may interact with specific receptors and signaling systems, render them valuable tools in the exploration of regulatory pathways

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Precise understanding of immunometabolic networks has been limited due to low abundance of DC subsets in the blood as well as challenges associated with bulk metabolic measurement which may not reflect natural temporal stochasticity and more recently recognized heterogeneity of ex-vivo cell cultures 22,23