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HSL overexpression led to a significant upregulation of the M2-master regulator PPAR and, critically, of genes involved in fatty acid -oxidation (FAO), including ACADVL and CPT1a (Fig

Additionally, experiments conducted on isolated bovine chondrocytes revealed an upregulation in the production of proteoglycans and collagen, fundamental components of the extracellular matrix essential for cartilage integrity

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