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in vitro that human SELENOP genes promoter was cytokine responsive

Its primary actions include: Increasing slow-wave (delta) sleep the deepest, most physically restorative sleep stage Modulating corticotropin-releasing hormone (CRH) reducing the HPA axis signalling that keeps cortisol elevated Influencing LH and somatostatin release both relevant to testosterone and growth hormone secretion Antioxidant activity preclinical data suggests DSIP has direct free-radical scavenging properties (3) Thermoregulatory effects potentially lowering basal body temperature in a manner consistent with natural sleep onset The net effect is not sedation

doi: 10.1097/MPH.0000000000002072 133 FarhatETeggEMohammedSGrzechnikEFavaloroEJ