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In animal studies, PPAR- agonists reduced IL-6 and TNF- expression in salivary glands while enhancing IL-4 production in serum, indicating a role in modulating the Th1/Th2 immune response balance [177]

By inhibiting the breakdown of stimulating neurotransmitters like norepinephrine and dopamine, Methylene Blue could cause feelings of anxiety, restlessness, or agitation in sensitive individuals, especially at higher doses

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