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J Pharmacol Exp Ther (2007) 323(3):787e793

Trotti D, Danbolt NC, Volterra A

A small amount of the drug is metabolized via the cytochrome P-450 pathway (to be specific, CYP3A4 and CYP2E1) into NAPQI, which is extremely toxic to liver tissue, as well as being a strong biochemical oxidizer