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Therefore, researchers speculated that DCs may also play a regulatory role in AILI, and proved not only the immunophenotype but also the secretion of inflammatory mediators in DCs change after APAP stimulation, including higher expression of MHC II and Toll-like receptors, and producing more IL-6, TNF-, etc

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Experimental investigations have shown that certain microbial metabolites, particularly SCFAs like butyrate and propionate, operate as HDAC inhibitors, increasing chromatin accessibility at BDNF promoter areas (particularly promoters I and IV)

AST produces oxaloacetate and glutamate, which support energy production in the Krebs cycle