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This methodology presents an issue with linking mechanistic actions of endocrine disrupting chemicals to the risk of disease development since endocrine dysfunction, especially within estrogenic pathways (e.g., menopausal status, menstrual cycle length, early menarche, and contraception use), are typically associated with reasons for hysterectomy (Upson and Missmer, 2020)

PMCID: PMC552978

Carskadon, M

6b, bottom panel) had first biopsy done over 3 years before beginning NAC therapy, suggesting that the intensity of staining in the skin may have been higher at the time NAC therapy began and that a potential response was masked by the time lag