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Here are the typical symptoms of B12 deficiency: Weakness, fatigue, tiredness, generally feeling run down Poor memory, brain fog ,light headedness and dizziness Depression (is involved in the synthesis of serotonin and dopamine) Heart palpitations, shortness of breath Pale skin A smooth tongue Lack of appetite Constipation, diarrhoea, gas, bloating

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Chemotherapy medications such as Fluorouracil: Fluorouracil can increase thiamin metabolism and block the formation of TDP, the active form of thiamin