B12 injections can be a powerful tool in a comprehensive approach to weight loss, particularly when combined with a healthy diet and regular exercise
(2000), Horm Res 53(Suppl 3), PubMed 10971106 Statistics from preclinical literature AOD-9604 = modified fragment of hGH 177191 + N-terminal Tyr (sequence Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe), molecular weight 1815.1 Da Developed at Metabolic Pharmaceuticals (Australia) based on the work of professor Frank Ng (Monash University) in the 1990s Standard experimental dose in obesity clinical trials: 1 mg/day subcutaneously (Phase 2b, Heffernan et al.) Mechanism: stimulation of 3-adrenergic receptors in adipose tissue, increased lipolysis and fatty acid oxidation without activation of the hGH receptor (no IGF-1 increase) Phase 2b clinical trial (2007, 300 patients): weight reduction ~2.8 kg vs placebo over 12 weeks FDA status: NDI rejection (2014) as a dietary supplement
Possible side effects include injection site pain or redness, mild diarrhea, nausea, itching, headache, or dizziness
Standard curves were constructed from 0.1 to 100 pg/mL and cytokine concentrations were calculated with SkanIt Software 4.1 for Microplate Readers RE, version 4.1.0.43 (ThermoFisher)
