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We have reported that the aldo-keto reductase 1 member B1 (AKR1B1) is activated in TNBC by Twist2, an inducer of EMT, and the accumulation of its major metabolite PGF2, in turn, activates NF-B signaling to upregulate Twist2 expression, which eventually forms a positive feedback loop to enhance the CSC properties in TNBC 88 ( Figure 2 )

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