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[DOI] [PMC free article] [PubMed] [Google Scholar] 188.Deponte M

These indoline-containing compounds exhibited potent and selective effects on KDM2A/7A at low micromolar concentrations, with notable cellular activity

For example, resveratrol (plant-derived phytoalexin) treatment triggers a strong signal for autophagy (p62 accumulation) through JNK activation leading to death in imatinib-resistant chronic myelogenic leukemia cells (CML) [369, 370]