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In a study published in the Journal of Orthopaedic Research (Staresinic et al., 2003), BPC-157 accelerated Achilles tendon healing in rats by approximately 72%, with biomechanical testing showing significantly greater tensile strength in treated tendons versus controls (N=72 rats, measured at 14 and 28 days)

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This initial phosphorylation cascade leads to autophosphorylation of the carboxy-terminal bidentate substrate-binding site (Tyr1349 and Tyr1356) of the c-Met and these residues have been shown as docking sites for downstream signaling molecules [52]