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Its use for wellness, detoxification, or skin brightening is considered "off-label." Off-label use is a common medical practice where a doctor prescribes a medication for a purpose different from its original FDA approval, based on professional judgment and scientific evidence

The discovery that NNMT expression is dramatically elevated in adipose tissue of obese humans and animal models, and that NNMT inhibition or knockdown prevents diet-induced obesity and improves metabolic health, has catalyzed intense research interest in NNMT as a therapeutic target for obesity, metabolic syndrome, and related conditions

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[DOI] [PubMed] [Google Scholar] 51.Zhang Z., Li W., Chang D., Wei Z., Wang E., Yu J., Xu Y., Que Y., Chen Y., Fan C., et al