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In the adult liver, LSECs exhibit distinct zonal markers 54 , which was recreated in the organoids where the endothelial structures acquire increasing CD54 + expression in proximity to the hepatocyte layer, which suggests that endothelial cell specialization is potentially a product of the niche (Fig

However, even with treatment using erythropoiesis-stimulating agents (ESAs) and iron supplements, approximately half of the patients exhibit a hypo-responsive or suboptimal correction of anemia, suggesting the involvement of other significant mechanisms in the development and progression of renal anemia

Beyond its role as a protector, it is essential for the detoxification processes in the liver, supports immune function, and helps recycle other antioxidants like Vitamin C and Vitamin E

doi: 10.1097/TP.0b013e3182366401 Summary Keywords organ preservation, transplantation, static cold storage, machine perfusion, graft quality, organ repair Citation Ran Q, Zhang J, Zhong J, Lin J, Zhang S, Li G and You B (2025) Organ preservation: current limitations and optimization approaches